Synthesis, Characterization, Antioxidant and Antibacterial Activities of Benzimidazole Compounds

In this work, the synthesis of Azo compound [A1-A3] from different amines, was carried out and then converted to the 2-substituted benzimidazole compound [B1-B3], through the interaction of the resulting azo compounds with O-phenylenediamine. The structures of all new synthesized compounds were determined by FT-IR, 1H NMR and 13C NMR and their physicochemical properties, among them solubility, color, and melting point. The synthesized benzimidazole compounds were also evaluated for their antioxidant activity using the DPPH radical scavenging assay and for their antibacterial activity against selected Gram-positive and Gram-negative bacteria. The results demonstrated that the synthesized compounds exhibited antioxidant and antibacterial activities with different levels of activity among the tested compounds.