Hubungan sistem kerja shift dan faktor kardiometabolik dengan hiperkolesterolemia pada perawat

Background: Hypercholesterolemia is an important cardiovascular risk factor. Shift-working nurses may experience circadian disruption, sleep disturbances, and irregular eating patterns that can affect lipid metabolism.Objectives: To examine associations of demographic, anthropometric, metabolic, and work-schedule characteristics with hypercholesterolemia among nurses at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This cross-sectional study analyzed secondary data from routine medical check-ups conducted between July and September 2025. All 1,207 eligible nurses were included. Variables were age, sex, body mass index, waist circumference, blood pressure, blood glucose, work schedule, and total cholesterol. Associations were assessed using chi-square tests and multivariable binary logistic regression.Results: Of 1,207 nurses, 849 (70.3%) worked shifts and 358 (29.7%) worked non-shift schedules. Hypercholesterolemia prevalence was 49.9%. In bivariate analysis, body mass index, blood pressure, blood glucose, and work schedule were associated with hypercholesterolemia; waist circumference was not. In multivariable analysis, age (aOR = 1.034 per year; 95% CI: 1.013–1.055), female sex (aOR = 2.326; 95% CI: 1.656–3.269), and work schedule (aOR = 146.16; 95% CI: 66.24–322.48) remained associated with hypercholesterolemia.Conclusions: Work schedule, age, and sex were independently associated with hypercholesterolemia among nurses. The cross-sectional design and the very large between-group difference in cholesterol warrant cautious interpretation and verification of data quality and model stability.