Hepatitis with a high degree of activity and multiple organ lesions on the background of Cytomegalovirus infection

Cytomegalovirus (CMV) is a widespread persistent infection capable of reactivation against the background of immunosuppression with the development of severe multiple organ lesions. Using the example of a clinical case, the article describes the development of an active CMV infection complicated by the formation of an autoimmune syndrome involving the liver (high-grade hepatitis), lungs (pneumonia, pulmonary embolism), peripheral nervous system (polyneuropathy) and joints (arthritis). This observation illustrates a rare variant of the course of a mixed infection, in which the reactivation of a persistent virus triggers a dominant autoimmune process leading to a chronic polysystemic disease with an uncertain prognosis. The case highlights the importance of including CMV in the differential diagnostic range for polysystemic and autoimmune syndromes, especially in patients with signs of immune dysfunction.