When would you expect buprenorphine plasma concentrations to exceed 10 nmol/L?

Buprenorphine plasma concentrations exceeding 10 nmol/L are typically reached with doses of 16 mg or more and can be significantly influenced by drug interactions such as with voriconazole. Clinicians must consider dosing adjustments and drug interactions to ensure therapeutic efficacy while minimizing risks. Monitoring is essential, especially in opioid-tolerant patients and those on extended-release formulations.