Prognostic Significance and Therapeutic Vulnerability of the Golgi-Mitochondria Contact Siteome Across Human Cancers: A Systematic Review and Integrative Bioinformatic Synthesis

• Context: Inter-organelle communication at Golgi-mitochondria contact sites (GMCs) plays a pivotal role in regulating non-vesicular lipid flux, organellar stress responses, and cell death pathways. • Problem: While preclinical evidence highlights targets like VDAC2, CERT, OSBP, and GDAP1 in cell death regulation, a comprehensive synthesis bridging preclinical findings with human clinical genomics (TCGA/GEO) across pan-cancer cohorts is currently lacking. • Objective: To systematically evaluate preclinical evidence regarding GMC target modulation in cancer cell death, while integratively analyzing human pan-cancer clinical cohorts to validate their prognostic value and therapeutic vulnerability.