A Liver-Targeted CIDEB siRNA in Adults with MASLD

A single dose of an siRNA targeting liver expression of CIDEB was associated with a reduction in liver fat of 58 to 80% at week 36 after treatment in persons with metabolic dysfunction–associated steatotic liver disease.

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Publication Details

Journal
New England Journal of Medicine
Published
2026-11-08
DOI
https://doi.org/10.1056/nejmc2612905
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

A Liver-Targeted CIDEB siRNA in Adults with MASLD

John D. Davis, Niek Verweij, Ned S. Braunstein, Kusha A Mohammadi et al.
5 links
New England Journal of Medicine
Liver Disease Diagnosis and Treatment
article

A Liver-Targeted CIDEB siRNA in Adults with MASLD

John D. Davis, Niek Verweij, Ned S. Braunstein, Kusha A Mohammadi, Thomas D. Norton, Aris Baras, Jennifer D. Hamilton, Fady Tanios, Susana Pereira, Luca Andrea Lotta, Mark W. Sleeman, Gavin H. Imperato, David J. Lederer, Meredith E. Crosby, Bret J. Musser, Madison Stoms, Sonya Aziz‐Zaman, Viktoria Gusarova, Jörg Täubel, Gary A. Herman, George D. Yancopoulos, David Workman, Terri A. Swanson, Rong Liu, Chao Chen, Yogesh Patel, Jessica D’Antonio, David Carl Smith, Jane Witkin, Vidya Xavier, Jutta Miller, Sean Smith, Ed Cox, Donato Forlenza, Shawn Fidotta, Joette Pindar, Justin Cho, Dinko Gonzalez Trotter, Shunguang Wang, Mauricio Leal, Shehla Habib, Xiping Cheng
article en

Abstract

A single dose of an siRNA targeting liver expression of CIDEB was associated with a reduction in liver fat of 58 to 80% at week 36 after treatment in persons with metabolic dysfunction–associated steatotic liver disease.

New England Journal of Medicine
Regeneron (United States) (US), Richmond Pharmacology Limited (United Kingdom) (GB)
Alnylam Pharmaceuticals, Regeneron Pharmaceuticals
Good health and well-being
Liver Disease Diagnosis and Treatment
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