A Liver-Targeted CIDEB siRNA in Adults with MASLD
A single dose of an siRNA targeting liver expression of CIDEB was associated with a reduction in liver fat of 58 to 80% at week 36 after treatment in persons with metabolic dysfunction–associated steatotic liver disease.
Authors
- John D. Davis (ORCID: https://orcid.org/0000-0001-6282-1670)
- Niek Verweij (ORCID: https://orcid.org/0000-0002-4303-7685)
- Ned S. Braunstein (ORCID: https://orcid.org/0009-0005-2463-3034)
- Kusha A Mohammadi (ORCID: https://orcid.org/0000-0002-7844-7537)
- Thomas D. Norton (ORCID: https://orcid.org/0009-0004-5896-9057)
- Aris Baras (ORCID: https://orcid.org/0000-0002-6830-3396)
- Jennifer D. Hamilton (ORCID: https://orcid.org/0000-0003-1236-5245)
- Fady Tanios
- Susana Pereira
- Luca Andrea Lotta (ORCID: https://orcid.org/0000-0002-2619-5956)
- Mark W. Sleeman (ORCID: https://orcid.org/0000-0002-3329-0919)
- Gavin H. Imperato
- David J. Lederer (ORCID: https://orcid.org/0000-0001-5258-0228)
- Meredith E. Crosby (ORCID: https://orcid.org/0000-0002-3626-9445)
- Bret J. Musser (ORCID: https://orcid.org/0000-0003-2949-211X)
- Madison Stoms
- Sonya Aziz‐Zaman
- Viktoria Gusarova (ORCID: https://orcid.org/0000-0002-2266-783X)
- Jörg Täubel (ORCID: https://orcid.org/0000-0002-0010-207X)
- Gary A. Herman (ORCID: https://orcid.org/0000-0003-4433-6529)
- George D. Yancopoulos
- David Workman
- Terri A. Swanson
- Rong Liu (ORCID: https://orcid.org/0000-0001-5170-6474)
- Chao Chen (ORCID: https://orcid.org/0000-0001-9526-0099)
- Yogesh Patel (ORCID: https://orcid.org/0000-0001-8948-4432)
- Jessica D’Antonio
- David Carl Smith (ORCID: https://orcid.org/0000-0002-9465-988X)
- Jane Witkin
- Vidya Xavier
- Jutta Miller
- Sean Smith
- Ed Cox
- Donato Forlenza
- Shawn Fidotta
- Joette Pindar
- Justin Cho
- Dinko Gonzalez Trotter
- Shunguang Wang
- Mauricio Leal
- Shehla Habib
- Xiping Cheng
Institutions
- Regeneron (United States) (US)
- Richmond Pharmacology Limited (United Kingdom) (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2026-11-08
- DOI
- https://doi.org/10.1056/nejmc2612905
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alnylam Pharmaceuticals
- Regeneron Pharmaceuticals