Immunosuppression PK: Tacrolimus & Cyclosporine

FREE EVALUATION SAMPLE (500 PATIENTS) This record contains a free, non-expiring evaluation sample (500 synthetic patients, 16,500 TDM visits) drawn exclusively from the training split of the Item 18 Corpus. There is zero data leakage into validation or test splits. Get the full 25,000-patient dataset (825,000 visits, full train/val/test splits, complete OMOP CDM v5.4 mapping) at: https://sentineldata.com.ua/dataset/immunosuppression-pk-tacrolimus-cyclosporine Executive Summary & The TDM Blind Spot In clinical organ transplantation, routine immunoassays measure whole-blood trough concentrations (Cwb). However, whole-blood measurements are heavily dominated by drug bound inside red blood cells. The pharmacologically active drug — unbound plasma concentration (Cu) that actually reaches lymphocytes — is virtually never measured in routine clinical practice. At low hematocrit, a whole-blood trough can appear reassuringly within the therapeutic window while the true active exposure is dangerously subtherapeutic. This is why biopsy-proven acute rejection frequently occurs in patients whose routine TDM numbers look completely normal. Immunosuppression PK bridges this gap. It provides exact latent ground truth (Cu, individual clearance CL, bioavailability F, volume of distribution Vc/Vp) paired with noisy observed whole-blood troughs (Cwb) across 33 TDM visits per patient. It is ... Full description with all tables is on the Wiki page of this project. Full dataset and purchase: https://sentineldata.com.ua/dataset/immunosuppression-pk-tacrolimus-cyclosporine . Zenodo copy: https://doi.org/10.5281/zenodo.22814996