Primary Squamous Cell Carcinoma of the Gallbladder: A Case Report

Abstract Background: Gallbladder carcinoma has a hidden onset and most cases are already in the advanced stage when diagnosed with a poor prognosis. The common type is adenocarcinoma, and primary gallbladder squamous cell carcinoma is the rarest histological type in Gallbladder carcinoma. Case presentation: A 56-year-old male was admitted to the hospital due to upper abdominal pain for 2 months without an obvious cause. The pain was more pronounced in the right upper abdomen, presenting as intermittent colicky pain, accompanied by radiating pain to the lower back. The microscopic examination demonstrated that Squamous metaplasia and dysplasia of the gallbladder epithelium were observed .The tumor consisted of well-differentiated squamous cell carcinoma tissue, which exhibited infiltrative growth into the subserosal fibrous and surrounding adipose tissue. Immunohistochemical staining showed the malignant cells were positive for P40, CK, CK5/6, CK19 and Ki-67 (index 60%) , weakly positive for CK7 and CEA. Pathological diagnosis indicated that well-differentiated squamous cell carcinoma of the gallbladder with infiltrative growth. Conclusion: This report describes an unusual case of squamous cell carcinoma of the gallbladder to enhance the clinical comprehension of this uncommon disease.