Vancomycin Precision-Dosing Cohort

VANCOMYCIN PRECISION-DOSING COHORT: METHODOLOGY, PHARMACOKINETICS AND VALIDATION SPECIFICATIONS GENERAL OVERVIEW The Vancomycin Precision-Dosing Cohort is a high-density, synthetic pharmacokinetic (PK) dataset constructed for the development, benchmarking, and validation of precision-dosing algorithms, Bayesian TDM forecasting engines, and Clinical Decision Support Systems (CDSS). The dataset models realistic therapeutic drug monitoring (TDM) scenarios across diverse inpatient populations, capturing intra-individual and inter-individual pharmacokinetic variability under continuous and intermittent intravenous infusion regimens. Full commercial dataset access (10,000 patients, 30,000 dosing regimens, 25.9M PK timepoints): https://sentineldata.com.ua/dataset/vancomycin-precision-dosing-10k 1. PHARMACOKINETIC METHODOLOGY & MATHEMATICAL FRAMEWORK 1.1 Structural Model Formulation The drug disposition kinetics are governed by a two-compartment mammillary pharmacokinetic model with first-order elimination from the central compartment and reversible distribution into a peripheral compartment: dC1/dt = (R_inf / V1) - ((CL + Q) / V1) * C1 + (Q / V2) * C2 dC2/dt = (Q / V1) * C1 - (Q / V2) * C2 Where: - C1: Vancomycin concentration in the central compartment (mg/L) - C2: Vancomycin concentration in the peripheral compartment (mg/L) - R_inf: Zero-order intravenous infusion rate (mg/h) - ... Full description with all tables is on the Wiki page of this project. Full dataset and purchase: https://sentineldata.com.ua/dataset/vancomycin-precision-dosing-10k . Zenodo copy: https://doi.org/10.5281/zenodo.22153221