Distributed data management for Genomics in the EOSC Federation: FORGE – Federating Open Research data for Genomics in EOSC

Description:Presentation given at the EOSC Symposium 2026 (Florence, October 2026) on FORGE, a cross-node use case of the EOSC Federation. FORGE demonstrates a “find–access–process” workflow for genomics data across EOSC Nodes: Find: a synthetic whole-genome sequencing dataset for colorectal cancer benchmarking (SPN01), stored on the ORFEO infrastructure of Area Science Park, is described with RO-Crate and published in the ICSC data catalogue of the Italian EOSC Node, together with machine-actionable access metadata. Access: the dataset is registered and replicated through the Rucio data management service of the CERN EOSC Node. Process: the data are retrieved and analysed on remote computing resources, namely the CERN REANA platform and the IT4LIA AI Factory. The presentation shows the architecture, the user journey from catalogue discovery to analysis, the results achieved and the lessons learned. FORGE (Distributed data management for Genomics in the EOSC Federation) was funded within the Cascading Grants of the EOSC Gravity Project (Horizon Europe, Grant Agreement No. 101188045). It was carried out by Area Science Park with the CERN EOSC Node and the Italian EOSC Node (Fondazione ICSC).