Immunotherapy Clonal Dynamics Cohort

This Zenodo record contains a free 100-patient sample only — not the full 10,000-patient dataset. Full dataset (10,000 patients, full technical documentation): https://sentineldata.com.ua/dataset/immunotherapy-clonal-dynamics-cohort Sample composition (true subset of the full cohort, not a separate generation): patients_sample.parquet — 100 rows; treatment_regimens_sample.parquet — 300 rows; outcomes_sample.parquet — 300 rows; clonal_profiles_sample.parquet — 72,300 rows. Dataset Architecture & Specifications The Immunotherapy Clonal Dynamics Cohort is a fully synthetic, mechanistically generated benchmark of tumor clonal dynamics under immune checkpoint inhibition (nivolumab, pembrolizumab, atezolizumab). Each of 10,000 synthetic patients is simulated under three counterfactual treatment arms on identical underlying biology, giving paired ground-truth comparisons no real-world trial can produce. 47.2% of generation constants are literature-verified (VERIFIED tier), the remainder are documented literature-anchored estimates (ESTIMATE_SOURCED), with zero unsourced values. Synthetic Patients 10,000 (3 counterfactual arms each) Treatment Regimens 30,000 (continuous / adaptive stop-resume / early aggressive) Clonal Profile Rows 7,230,000 (0-120 days, 0.5-day step) Data Schema Columnar Parquet (Snappy), 100% reproducible via Master Seed 20260828 Tumor-Immune-PK Model & Governing ... Full description with all tables is on the Wiki page of this project. Full dataset and purchase: https://sentineldata.com.ua/dataset/immunotherapy-clonal-dynamics-cohort . Zenodo copy: https://doi.org/10.5281/zenodo.22663764