Mutational and phenotypic landscape of circulating vaccine‐derived Poliovirus 2 in sewage in a high vaccine coverage area
The final phases of the Global Polio Eradication Initiative are challenged by the circulation of vaccine-derived polioviruses, particularly serotype 2, occurring even in certified polio-free countries. Integrated environmental surveillance and long-read deep sequencing enable resolution of the viral haplotype network. Structural modelling of this network reveals the poliovirus phenotypic landscape. Together, these approaches uncover the complete poliovirus quasispecies in a population of approximately 1.8 million inhabitants.
Authors
- Albert Carcereny (ORCID: https://orcid.org/0000-0002-9615-7576)
- Cristina Fuentes (ORCID: https://orcid.org/0000-0002-6136-1593)
- Jaume C. Jorba (ORCID: https://orcid.org/0000-0001-6552-9878)
- María Cabrerizo (ORCID: https://orcid.org/0000-0001-7054-5696)
- Rosa M Pintó (ORCID: https://orcid.org/0000-0003-1382-6648)
- Miquel Paraira
- David García-Pedemonte (ORCID: https://orcid.org/0000-0001-8375-8797)
- Susana Guix (ORCID: https://orcid.org/0000-0002-1588-3198)
- Ian Pérez (ORCID: https://orcid.org/0000-0002-6648-9852)
- Albert Bosch (ORCID: https://orcid.org/0000-0002-8111-9059)
- María Isabel Costafreda (ORCID: https://orcid.org/0000-0002-3114-3034)
- Albert Blanco
- Jacobo Mendioroz
- Javier Martin
- Belen Galofré
Institutions
- Centers for Disease Control and Prevention (US)
- Instituto de Salud Carlos III (ES)
- Hospital La Paz Institute for Health Research (ES)
- Agència de Salut Pública de Catalunya (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Medicines and Healthcare products Regulatory Agency (GB)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- iMetaOmics.
- Published
- 2026-11-07
- DOI
- https://doi.org/10.1002/imo2.70153
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention