Evaluation of Wound Healing Potential of A Polyherbal Formulation Prepared From Sterculia foetida and Psoralea Corylifolia seeds

The present study was undertaken to develop and evaluate a polyherbal ointment containing methanolic seed extracts of Sterculia Foetida and Psoralea Corylifolia for wound healing. Preliminary phytochemical screening confirmed the presence of important bioactive constituents, while quantitative analysis revealed higher total phenolic (39.26 mg GAE/g) and flavonoid (46.57 mg RE/g) contents in Sterculia Foetida than in Psoralea Corylifolia. Three ointment formulations were prepared and evaluated for physicochemical properties, antimicrobial activity, and wound healing efficacy. All formulations exhibited acceptable pH, viscosity, spreadability, and were non-irritant, indicating their suitability for topical application. The polyherbal ointment showed superior antibacterial activity against Staphylococcus aureus with a zone of inhibition of 18.3 mm and produced 75.50 ± 0.46% wound closure by Day 21, compared with the individual herbal formulations. Although the standard 0.2% Nitrofurazone ointment exhibited the highest wound healing response, the polyherbal formulation demonstrated significantly enhanced healing due to the synergistic action of the combined plant extracts. The findings suggest that the developed polyherbal ointment is a safe and promising natural topical formulation for wound management.