ORBIT-PK: THREE-DRUG SPACEFLIGHT PK CALIBRATED

FREE SAMPLE INCLUDED. This record contains the full technical documentation and a free evaluation sample (600 subjects, 7,200 observation rows), not the full dataset. The complete dataset (105,000 subjects, 6 Apache Parquet tables, 1,260,000 observation rows) is available here: https://sentineldata.com.ua/dataset/orbit-pk-three-drug-spaceflight-pk-calibrated About the dataset: ORBIT-PK is a fully synthetic pharmacokinetic dataset of 105,000 simulated adults on three real drugs (acetaminophen, scopolamine, zolpidem), oral and transdermal patch, built to show how a drug's behaviour in microgravity differs from the ground. Each subject is an instance of an explicit two-compartment model solved by matrix exponentiation, with exact noise-free PK parameters kept in separate tables next to noisy 12-point concentration curves. For acetaminophen, each flight subject is resampled from one of four real in-flight comparisons that disagree with each other, and scopolamine's oral flight arm comes from the one real comparison that exists. Zolpidem and the scopolamine patch have no published in-flight data and ship ground-only. 41 of 41 structural checks passed; 8 of 10 published-literature benchmarks passed and 2 are disclosed failures. 42 cited sources. Model-generated data, not for clinical dosing. Full description with tables is on the Wiki page of this project. Zenodo copy: https://doi.org/10.5281/zenodo.24018154