D3.1. Detailed protocols for each liquid biopsy pilot study

The primary objective is to define, collect, and harmonize standard operational protocols for the 7 Liquid Biopsy Pilot Studies planned in SPARC. These pilot studies span multiple oncology indications, including more than 11 cancers. Moreover, they are designed to drive the real-world clinical implementation of liquid biopsy across European healthcare systems.To achieve technical rigor and inter-centre comparability across heterogeneous European healthcare settings, WP3 executed a structured operational strategy. This included a baseline survey (M2–M4), a centralized Excel Pilot Monitoring Tool (M8) for real-time tracking of the pilot progress, and a standardized Protocol Template (M9). Together, these tools establish minimum requirements across pre-analytical, analytical, and clinical workflows, directly supporting the progression of each pilot along the Translation Level of Study (TLS) scale.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-06
DOI
https://doi.org/10.5281/zenodo.24010746
Primary Topic
Cancer Genomics and Diagnostics
Type
article
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article

D3.1. Detailed protocols for each liquid biopsy pilot study

Michaela Luconi, Andrea Galli, Manuel Ottaviano, Eloísa Jantus‐Lewintre et al.
3 links
Zenodo (CERN European Organization for Nuclear Research)
Cancer Genomics and Diagnostics
article

D3.1. Detailed protocols for each liquid biopsy pilot study

Michaela Luconi, Andrea Galli, Manuel Ottaviano, Eloísa Jantus‐Lewintre, Brune de Dreuille, Serena Pillozzi, Cristina Muntañola-Valero
article en

Abstract

The primary objective is to define, collect, and harmonize standard operational protocols for the 7 Liquid Biopsy Pilot Studies planned in SPARC. These pilot studies span multiple oncology indications, including more than 11 cancers. Moreover, they are designed to drive the real-world clinical implementation of liquid biopsy across European healthcare systems.To achieve technical rigor and inter-centre comparability across heterogeneous European healthcare settings, WP3 executed a structured operational strategy. This included a baseline survey (M2–M4), a centralized Excel Pilot Monitoring Tool (M8) for real-time tracking of the pilot progress, and a standardized Protocol Template (M9). Together, these tools establish minimum requirements across pre-analytical, analytical, and clinical workflows, directly supporting the progression of each pilot along the Translation Level of Study (TLS) scale.

Zenodo (CERN European Organization for Nuclear Research)
Azienda Ospedaliero-Universitaria Careggi (IT), Madrid Health Service (ES), Fundacio Investigacio Hospital General Universitari De Valencia (ES), Hospital General Universitario De Valencia (ES), University of Florence (IT), Universitat Politècnica de València (ES), University of Arkansas at Fayetteville (US), Universidad Politécnica de Madrid (ES)
Good health and well-being
Openalex Percentile: Top 21%
Cancer Genomics and Diagnostics
DOIOpen Access PDFOpenAlex
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