Hematological and Clinical Effects of Jackfruit Leaf (Artocarpus heterophyllus) Extract in Javanese Thin-Tailed Sheep Infected with Haemonchus contortus

Abstract This study was conducted to evaluate the effect of jackfruit leaf extract on sheep in blood profile, and assessing clinical parameters.The experiment was carried out at the UGM Integrated Testing Laboratory, the Small Livestock Laboratory of the Agricultural Development Polytechnic. A Completely Randomized Design (CRD) was applied. The sample size was determined using the Federer formula: (n − 1)(t − 1) ≥ 15, where t represents the number of treatment groups and n represents the number of samples.A total of 25 female sheep were divided into five groups (five animals per group): P0 (0% dose, negative control), P1 (0.6% dose), P2 (1.2% dose), P3 (positive control treated with Albendazole), and P4 (healthy, worm-free sheep as an additional positive control).The results showed that jackfruit leaves contain total tannins of 235.6 mg/g, condensed tannins of 0.26 mg/g, saponins of 1.49 mg/g, and flavonoids of 1.53mg/g, indicating their potential as anthelmintic agents. Jackfruit leaf extract significantly increased weekly weight gain in thin-tailed sheep, significantly improved blood profile parameters, and had a significant effect on clinical indicators, including anemia status (FAMACHA© score) and dag score in sheep infected with Haemonchus contortus