SYNTHESIS OF MORPHOLINE-CONTAINING 6H-1,3,4-THIADIAZINES BASED ON Α-BROMOHYDROXYKETONES
The article investigates the synthesis and formation mechanism of morpholine-containing 1,3,4-thiadiazine heterocycles. The reactions of α-bromo-3-methyl-3-hydroxybutan-2-one and α-bromo-3-methyl-3-hydroxypentan-2-one with morpholine-4-carbothiohydrazide are analyzed, with particular attention to the effects of tautomeric equilibrium, solvent, and alkaline conditions on the reaction pathway. The structures of the obtained compounds were confirmed by ¹H NMR and IR spectroscopy.
Authors
- Э. Х. Пулатов (ORCID: https://orcid.org/0000-0002-0052-5961)
- Т. Х. Абдуллаев (ORCID: https://orcid.org/0000-0003-2630-8540)
- Muzafar D. Isobaev (ORCID: https://orcid.org/0000-0001-5664-1956)
- Nushervon Hayotov (ORCID: https://orcid.org/0009-0008-4382-5439)
- Boronkul G. Mavlonov (ORCID: https://orcid.org/0009-0008-5339-9744)
Institutions
- Academy of Sciences of the Republic of Tajikistan (TJ)
- Institute of Chemistry named after V.I. Nikitin (TJ)
Publication Details
- Journal
- Journal of Chemistry of Goods and Traditional Medicine
- Published
- 2026-11-06
- DOI
- https://doi.org/10.55475/jcgtm/vol5.iss4.2026.711
- Primary Topic
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00