Suramin inspires next-generation broad-spectrum antiviral design targeting RdRps
Structural studies of diverse viral RNA-dependent RNA polymerases reveal that the broad-spectrum antiviral Suramin binds distinct sites while repeatedly exploiting conserved RNA-interacting and electrostatic features. This Pearl highlights common vulnerabilities within viral RNA polymerases and discusses how structural studies provide a framework for future antiviral design.
Authors
- Bin Liu (ORCID: https://orcid.org/0000-0002-6581-780X)
- Fan Bu (ORCID: https://orcid.org/0000-0003-3697-1477)
- Ge Yang (ORCID: https://orcid.org/0000-0002-5085-4261)
- Arwen Baer
Institutions
- University of Minnesota (US)
- Gustavus Adolphus College (US)
Publication Details
- Journal
- PLoS Pathogens
- Published
- 2026-11-06
- DOI
- https://doi.org/10.1371/journal.ppat.1014766
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Minnesota
- National Institutes of Health
- National Institute of General Medical Sciences