Performance Evaluation and Validation of a Next-Generation Sequencing-Based Measurable Residual Disease Assay for FLT3 Internal Tandem Duplication Detection in Acute Myeloid Leukemia
Background: -ITDs) in measurable residual disease (MRD) remains challenging due to structural heterogeneity and the limited sensitivity of conventional methods. Methods: -ITDs in AML. Results: -ITD clones identified in 35.0% of patients and frequent detection of low-level microclones. Longitudinal analysis further revealed diverse clonal dynamics. Conclusions: -ITDs and enables high-resolution assessment of clonal dynamics, supporting its clinical utility for MRD monitoring in AML.
Authors
- Yonggoo Kim (ORCID: https://orcid.org/0000-0003-2808-3795)
- Myungshin Kim (ORCID: https://orcid.org/0000-0001-8632-0168)
- Byung‐Sik Cho (ORCID: https://orcid.org/0000-0002-4524-6616)
- Bit Na Kwon (ORCID: https://orcid.org/0009-0005-0890-7023)
- Sungkyu Kyung (ORCID: https://orcid.org/0009-0007-5724-7417)
- Jong‐Mi Lee (ORCID: https://orcid.org/0000-0003-2890-5285)
- Hee‐Je Kim (ORCID: https://orcid.org/0000-0003-4098-3366)
- Ji Yeon Kim (ORCID: https://orcid.org/0009-0007-7898-4475)
Institutions
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Annals of Laboratory Medicine
- Published
- 2026-11-06
- DOI
- https://doi.org/10.3343/alm.2026.0252
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00