NEOSOMES, AS NOVEL VESICULAR CARRIER FOR ENHANCED TRANSDERMAL DRUG DELIVERY OF NSAIDS: A COMPREHENSIVE REVIEW WITHLIPOSOMES

Neosomes are vesicular nanocarriers that have gained attention as potential systems for transdermal drug delivery. They may help improve drug penetration, retain drugs within the skin for prolonged release, and control the rate at which drugs enter systemic via the skin. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to manage pain and inflammation; however, their oral administration may cause gastrointestinal side effects. Transdermal drug delivery offers an alternative way to improve drug delivery while reducing systemic adverse effects. Neosomes and liposomes are the vesicular carriers that enhance the drug penetration power through the skin and improves therapeutic efficacy. This review discusses the formulation, characteristics, and applications of neosomes for the transdermal delivery of NSAIDs, with a comparative overview of liposomes. It also describes their advantages, limitations, and future potential in developing effective and patient-friendly drug delivery systems.