A live agent benchmark of independent action authorization for healthcare AI agents

Abstract Benchmarks measure what healthcare AI agents can do, not what they may be authorized to do. We built a live-agent benchmark holding task, model, prompt and tools fixed, varying only whether an independent authorization layer gated execution. 576 synthetic care-coordination episodes ran under four arms: deterministic rules, an unconstrained agent, a gateway-governed agent, and a gateway plus autonomy controller. Episodes carry hidden truth and a lossy observable projection, so the gateway can both wrongly authorize and wrongly block. A prespecified rule set blinded to arm adjudicated safety. Unsafe actions occurred in 0.7% of fully governed versus 0.4% of unconstrained episodes (+ 0.4 points, 95% CI -0.5 to + 1.2, P = 0.6875). Routine task success, escalation accuracy, and calibration were each significantly worse under full governance, which also required more time and human effort. These synthetic findings use rule-based adjudication, lack a human comparator, and do not establish clinical effectiveness.

Authors

Publication Details

Journal
Research Square
Published
2026-11-06
DOI
https://doi.org/10.21203/rs.3.rs-11133816/v1
Primary Topic
Artificial Intelligence in Healthcare and Education
Type
preprint
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preprint

A live agent benchmark of independent action authorization for healthcare AI agents

Senapati Lipsa
1 links
Research Square
Artificial Intelligence in Healthcare and Education
preprint

A live agent benchmark of independent action authorization for healthcare AI agents

Senapati Lipsa
preprint en

Abstract

Abstract Benchmarks measure what healthcare AI agents can do, not what they may be authorized to do. We built a live-agent benchmark holding task, model, prompt and tools fixed, varying only whether an independent authorization layer gated execution. 576 synthetic care-coordination episodes ran under four arms: deterministic rules, an unconstrained agent, a gateway-governed agent, and a gateway plus autonomy controller. Episodes carry hidden truth and a lossy observable projection, so the gateway can both wrongly authorize and wrongly block. A prespecified rule set blinded to arm adjudicated safety. Unsafe actions occurred in 0.7% of fully governed versus 0.4% of unconstrained episodes (+ 0.4 points, 95% CI -0.5 to + 1.2, P = 0.6875). Routine task success, escalation accuracy, and calibration were each significantly worse under full governance, which also required more time and human effort. These synthetic findings use rule-based adjudication, lack a human comparator, and do not establish clinical effectiveness.

Research Square
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Artificial Intelligence in Healthcare and Education
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