Progression‐Associated Loss of SMARCB1/INI1 Expression in Mismatch Repair‐Deficient Glioblastoma
A mismatch repair-deficient glioblastoma acquired a second SMARCB1 mutation with complete loss of SMARCB1 protein expression at recurrence. Acquired SMARCB1 deficiency may represent a progression-associated event in mismatch repair-deficient glioblastoma and constitute a diagnostic pitfall.
Authors
- Abigail Kora Suwala (ORCID: https://orcid.org/0009-0003-8394-1905)
- Christian Thomas (ORCID: https://orcid.org/0000-0002-6642-7774)
- Martin Hasselblatt (ORCID: https://orcid.org/0000-0003-2707-8484)
- Enrico G. Kuellenberg (ORCID: https://orcid.org/0000-0002-9898-7100)
- Nils Warneke
- Markus Holling (ORCID: https://orcid.org/0000-0002-2167-0789)
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Hospital Münster (DE)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2026-11-06
- DOI
- https://doi.org/10.1111/nan.70105
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00