Quinazoline Derivatives as Emerging Therapeutic Scaffolds : A Comprehensive Review

Quinazoline is a bicyclic nitrogen-containing heterocycle that has attracted significant attention in medicinal chemistry due to its broad spectrum of biological activities. A diverse range of molecules having quinazoline moiety are reported to show a broad range of medicinal activities like antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, antibacterial, antioxidant and other activities. Structural modification of the quinazoline scaffold has led to the development of several clinically useful drugs. This review highlights the importance of quinazoline and quinazolinone derivatives, their structural features, and their biological activities against various diseases.