Effective trialing of digital interventions in daily life – the mental health perspective

Abstract Digital mental health interventions show promise but have yet to meet expectations. We discuss gaps between promising results of pilot studies and null findings in randomized controlled trials, focusing on two major approaches: just-in-time relapse prevention and just-in-time adaptive interventions. We propose that relapse prevention will profit from long-term studies capturing emerging episodes, and we suggest a novel framework for adaptive interventions including causality testing to proceed towards effective trialing.

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Publication Details

Journal
npj Digital Medicine
Published
2026-11-06
DOI
https://doi.org/10.1038/s41746-026-03414-7
Primary Topic
Digital Mental Health Interventions
Type
article
Field-Weighted Citation Impact
0.00

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article

Effective trialing of digital interventions in daily life – the mental health perspective

Markus Reichert, Ulrich Ebner‐Priemer, Lorenz Deserno
1 links
npj Digital Medicine
Digital Mental Health Interventions
article

Effective trialing of digital interventions in daily life – the mental health perspective

Markus Reichert, Ulrich Ebner‐Priemer, Lorenz Deserno
article en

Abstract

Abstract Digital mental health interventions show promise but have yet to meet expectations. We discuss gaps between promising results of pilot studies and null findings in randomized controlled trials, focusing on two major approaches: just-in-time relapse prevention and just-in-time adaptive interventions. We propose that relapse prevention will profit from long-term studies capturing emerging episodes, and we suggest a novel framework for adaptive interventions including causality testing to proceed towards effective trialing.

npj Digital MedicineVol. 9(1)
Karlsruhe Institute of Technology (DE), University of Salzburg (AT), Heidelberg University (DE), Central Institute of Mental Health (DE), Universitätsklinikum Würzburg (DE), Medizinische Fakultät Mannheim (DE), Deutsches Zentrum für Psychische Gesundheit (DE)
Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung
Good health and well-being
Openalex Percentile: Top 11%
Digital Mental Health Interventions
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Effective trialing of digital interventions in daily life – the mental health perspective — Markus Reichert, Ulrich Ebner‐Priemer, et al. · npj Digital Medicine (2026) | TGRS Research Map | TGRS