What does a low C-peptide level indicate in the context of high HbA1c in a patient?

Low C-peptide levels in the context of high HbA1c generally suggest decreased endogenous insulin production, pointing to significant beta-cell dysfunction, commonly seen in type 1 diabetes and LADA. Evidence for exactly predicting outcomes is limited and context-dependent.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-05
DOI
https://doi.org/10.5281/zenodo.23982844
Primary Topic
Diabetes and associated disorders
Type
article
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article

What does a low C-peptide level indicate in the context of high HbA1c in a patient?

Tripdatabase
Zenodo (CERN European Organization for Nuclear Research)
Diabetes and associated disorders
article

What does a low C-peptide level indicate in the context of high HbA1c in a patient?

Tripdatabase
article en

Abstract

Low C-peptide levels in the context of high HbA1c generally suggest decreased endogenous insulin production, pointing to significant beta-cell dysfunction, commonly seen in type 1 diabetes and LADA. Evidence for exactly predicting outcomes is limited and context-dependent.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 20%
Diabetes and associated disorders
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What does a low C-peptide level indicate in the context of high HbA1c in a patient? — Tripdatabase · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS