Single-cell atlas of glomerular injury in a mouse model of Alzheimer's disease

Alzheimer's disease (AD) is one of the leading causes of dementia in the elderly population. Once regarded primarily as a neurodegenerative disease of the central nervous system, AD is now increasingly recognized as a systemic disease, with a "brain-kidney" pathological crosstalk axis implicated in disease progression. In this study, 12-week-old and 32-week-old wild-type mice and FAD4T model mice were selected, and single-cell transcriptomic data of glomeruli were obtained using the Stereo-cell single-cell sequencing platform to analyze cellular heterogeneity during AD progression.