Formulation, Optimization and Evaluation of a Tulsi Herbal Oral Dissolving Film.

In recent years, Oral Thin Films (OTFs) Have attracted considerable attention from scientists and researchers in pharmaceutical formulation development and are Considered a potential technology for designing effective drug delivery systems. These films are generally formulated using hydrophilic polymers, plasticizers, and flavoring substances, which contribute to rapid hydration, adequate mechanical properties, and improved taste acceptability. According to their drug-release profiles, OTFs Can be divided into three distinct categories main types: fast-dissolving films, melt-away mucoadhesive films, and sustained-release wafers.In this investigation, many film formulations containing the medicine were created with various polymers and plasticizers to select the best with the optimal and needed properties. The film was created using the solvent casting process. The MDS was optimised using a full factorial design. The concentration of film former (HPMC-E15) and plasticizer were independent variables in this study (PEG-400). The response for This configuration was chosen according to disintegration time, folding endurance, and percent drug release after 5 minutes. A Comprehensive Overview of Oral Thin Films: Applications, Preparation Methods, and Recent Research Advances