A REVIEW ON NANOTECHNOLOGY BASED STRATEGIES FOR ENHANCHING THE ANTI- INFLAMMATORY ACTIVITY OF POORLY BIO AVAILABLE DRUGS AND NATURAL BIO ACTIVES

Nanotechnology based drug delivery systems have emerged as promising approaches to overcome selected limitations of convectional formulations and improve therapeutic performance. This review aims to provide a comprehensive overview of nanotechnology-based formulation strategies for enhancing the bioavailability and anti-inflammatory efficacy of synthetic drugs and natural bioactive compounds, with particular emphasis on formulation approaches, underlying mechanisms, recent advances and translational challenges. Various nanocarrier systems, including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, polymeric nanoparticles, nano emulsion are discussed in relation to their physicochemical properties and drug delivery potential. Nanotechnology-based formulations offer considerable potential for addressing important pharmaceutical and pharmacokinetic limitations of anti-inflammatory agents. Particular attention is given to natural bio actives such as curcumin, quercetin and resveratrol and to emerging strategies involving targeted delivery, and combination therapy.