Mechanism of Action and Synthesis of Mezlocillin

Mezlocillin is an extended-spectrum, semisynthetic ureidopenicillin antibiotic. Overview & Mechanism • Class: Extended-spectrum beta-lactam penicillin/acylureido. • Mechanism: Produces a bactericidal action by preventing the formation of bacterial cell walls. • Spectrum: Effective against a variety of anaerobic bacteria (such as Bacteroides fragilis), Gram-negative bacilli (such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella, and Proteus), and Gram-positive cocci (such as streptococci and enterococci). Pharmacokinetics • Administration: Intramuscular (IM) or intravenous (IV) injection (poorly absorbed orally). • Half-life: 60–66 minutes, or around 0.7–1.1 hours. • Excretion: Mainly removed via biliary excretion and the kidneys (urine). • The range of protein binding is 16% to 42%. Clinical Indications · Infections of the lower respiratory tract · UTIs, or urinary tract infections · Infections of the skin and skin structure · Peritonitis and intra-abdominal infections · Infections related to gynecology · Infections of the bones and joints (osteomyelitis) · Bacteremia or septicemia