CD20-directed Autologous CAR T-cell Therapy for Waldenström Macroglobulinemia
No chimeric antigen receptor therapy (CAR-T) is currently approved for WM. This study assessed safety and efficacy of CD20-targeted CAR-T in BTKi-refractory, heavily pre-treated WM patients. With a CR/VGPR rate of 80%, this treatment should be evaluated in larger trials. ClinicalTrials.gov number NCT03277729
Authors
- Ajay K. Gopal (ORCID: https://orcid.org/0000-0003-3023-6834)
- Cathee Till (ORCID: https://orcid.org/0000-0002-6801-8333)
- Jordan Gauthier (ORCID: https://orcid.org/0000-0002-5769-8409)
- Marie Bleakley (ORCID: https://orcid.org/0000-0002-7018-8702)
- David G. Maloney (ORCID: https://orcid.org/0000-0002-8477-6919)
- Manuel Litchman
- Aude G. Chapuis (ORCID: https://orcid.org/0000-0002-9574-5448)
- Brian G. Till (ORCID: https://orcid.org/0000-0002-4718-8288)
- Kelsey K. Baker (ORCID: https://orcid.org/0000-0002-8062-8839)
- Alexandre V. Vinaud Hirayama (ORCID: https://orcid.org/0000-0001-7980-3882)
- Mary Weber Redman (ORCID: https://orcid.org/0000-0003-2294-9674)
- Mary Kwok (ORCID: https://orcid.org/0000-0002-3002-8130)
- Mazyar S. Shadman (ORCID: https://orcid.org/0000-0002-3365-6562)
- Lorenzo Iovino (ORCID: https://orcid.org/0000-0002-3165-1899)
- Folashade Otegbeye (ORCID: https://orcid.org/0000-0002-9978-4719)
- Edus Houston Warren (ORCID: https://orcid.org/0000-0002-9570-2755)
- Cecilia C.S. Yeung (ORCID: https://orcid.org/0000-0001-6799-2022)
- Ryan Daniel Cassaday (ORCID: https://orcid.org/0000-0002-3424-2425)
- Chaitra Shankar Ujjani (ORCID: https://orcid.org/0000-0003-1977-1510)
- Xiaoling Song (ORCID: https://orcid.org/0000-0001-5969-4025)
- Sang Y. Lee (ORCID: https://orcid.org/0000-0001-6938-3781)
- Bruce J Dezube
- Dong Hoon Lee
- David HongZhao Qian
Institutions
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Blood
- Published
- 2026-11-05
- DOI
- https://doi.org/10.1182/blood.2026034987
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00