Targeting hormone conversion through dietary fiber improves polyendocrine metabolic ovarian syndrome

Excessive androgens serve as a primary driver for many phenotypic features of polyendocrine metabolic ovarian syndrome (PMOS). Although dietary fiber has been shown to alleviate PMOS, its effects on androgen concentrations and the underlying mechanisms remain unclear. In a clinical trial, we demonstrated that a dietary fiber combination consisting of inulin, resistant starch, and β-glucan reduces androgen concentrations in patients’ plasma. Mechanistically, dietary fiber increased the abundance of Bacteroides xylanisolven s, which converts androstenedione into a nonandrogenic secondary hormone metabolite we named coproandrosterone, which is further metabolized by gut microbiota into dihydro-coproandrosterone. This metabolic pathway was validated in a mouse model. These findings highlight the potential of dietary fiber to alleviate PMOS by modulating androgen homeostasis through gut microbiota, offering insights for prebiotic and probiotic therapies.

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Publication Details

Journal
Science
Published
2026-11-05
DOI
https://doi.org/10.1126/science.aed8952
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Targeting hormone conversion through dietary fiber improves polyendocrine metabolic ovarian syndrome

Manfei Si, Jie Qiao, Changtao Jiang, 郑建淮 et al.
Science
Gut microbiota and health
article

Targeting hormone conversion through dietary fiber improves polyendocrine metabolic ovarian syndrome

Manfei Si, Jie Qiao, Changtao Jiang, 郑建淮, Yanli Pang, Qixing Nie, Hongyu Niu, Meng Li, Shaoping Nie, Xiaoyu Long, Chenghao Guo, Bangjian Dong, Hong Chen, Kai Wang, Yong Ding, Xinyu Qi, Xianglei Xiong, Haohan Ma, Xi Luo, Shuqi Wu, Yicun Wang
article en

Abstract

Excessive androgens serve as a primary driver for many phenotypic features of polyendocrine metabolic ovarian syndrome (PMOS). Although dietary fiber has been shown to alleviate PMOS, its effects on androgen concentrations and the underlying mechanisms remain unclear. In a clinical trial, we demonstrated that a dietary fiber combination consisting of inulin, resistant starch, and β-glucan reduces androgen concentrations in patients’ plasma. Mechanistically, dietary fiber increased the abundance of Bacteroides xylanisolven s, which converts androstenedione into a nonandrogenic secondary hormone metabolite we named coproandrosterone, which is further metabolized by gut microbiota into dihydro-coproandrosterone. This metabolic pathway was validated in a mouse model. These findings highlight the potential of dietary fiber to alleviate PMOS by modulating androgen homeostasis through gut microbiota, offering insights for prebiotic and probiotic therapies.

ScienceVol. 394(6824)
Nanchang University (CN), Peking University (CN), Peking University Third Hospital (CN), Center for Life Sciences (CN)
Openalex Percentile: Top 26%
Gut microbiota and health
DOISourceOpenAlex
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