Tyrosine kinase inhibitors are associated with reduced AML transformation in systemic mastocytosis with myeloid neoplasm
In an international registry analysis of 201 patients with SM-AHN, KIT D816V-selective TKI exposure was associated with longer overall survival (37.9 vs 17.8 months; P <.001) and lower 36-month incidence of acute myeloid leukemia transformation (5.9% vs 27.1%; P <.001).
Authors
- Cristina Bulai Livideanu (ORCID: https://orcid.org/0000-0002-5275-6868)
- Johannes Nikolaus Woltsche (ORCID: https://orcid.org/0000-0002-2240-6736)
- Maël Heiblig (ORCID: https://orcid.org/0000-0003-1682-8657)
- Peter Valent (ORCID: https://orcid.org/0000-0003-0456-5095)
- Julien Rossignol (ORCID: https://orcid.org/0000-0003-3052-1424)
- Akif Selim Yavuz (ORCID: https://orcid.org/0000-0001-9049-4654)
- Paul L. A. van Daele (ORCID: https://orcid.org/0000-0003-1832-337X)
- Deborah Christen (ORCID: https://orcid.org/0000-0003-2839-5983)
- Jens Panse (ORCID: https://orcid.org/0000-0001-6316-3112)
- Sophie Dimicoli (ORCID: https://orcid.org/0000-0002-1772-4545)
- Andrzej Mital (ORCID: https://orcid.org/0000-0003-0854-3096)
- Knut Brockow (ORCID: https://orcid.org/0000-0002-2775-3681)
- Michael P. Makris (ORCID: https://orcid.org/0000-0003-2713-2380)
- Mattias Mattsson (ORCID: https://orcid.org/0000-0002-9510-8801)
- Chiara Elena (ORCID: https://orcid.org/0000-0002-0058-7142)
- Irena Angelova‐Fischer (ORCID: https://orcid.org/0000-0002-2289-3626)
- Christine M. Breynaert (ORCID: https://orcid.org/0000-0002-7368-1068)
- Martina Sperr
- Marc Heizmann (ORCID: https://orcid.org/0000-0003-3818-8638)
- Juliana Schwaab (ORCID: https://orcid.org/0000-0001-9208-5264)
- Friederike Wortmann (ORCID: https://orcid.org/0000-0002-8684-1710)
- Marek Niedoszytko (ORCID: https://orcid.org/0000-0003-1089-1911)
- Horia Bumbea (ORCID: https://orcid.org/0000-0002-3706-3166)
- Valentina Bellani (ORCID: https://orcid.org/0009-0008-9561-5564)
- Sotirios G. Papageorgiou (ORCID: https://orcid.org/0000-0002-3376-837X)
- Michel Arock (ORCID: https://orcid.org/0000-0002-3990-4408)
- Hanneke C. Kluin‐Nelemans (ORCID: https://orcid.org/0000-0003-2617-9427)
- Vito Sabato (ORCID: https://orcid.org/0000-0002-1321-314X)
- Anna Belloni Fortina (ORCID: https://orcid.org/0000-0001-5791-0775)
- Saskia K. Klein (ORCID: https://orcid.org/0000-0001-8847-2704)
- Massimo Triggiani (ORCID: https://orcid.org/0000-0001-7318-2093)
- Axel Rüfer (ORCID: https://orcid.org/0000-0003-2617-1724)
- Aleksandra Górska (ORCID: https://orcid.org/0000-0001-6682-1555)
- Olivier Tournilhac (ORCID: https://orcid.org/0000-0002-9438-621X)
- Frank Siebenhaar (ORCID: https://orcid.org/0000-0003-4532-1644)
- Simge Erdem (ORCID: https://orcid.org/0000-0001-8095-5445)
- Khalid Shoumariyeh (ORCID: https://orcid.org/0000-0001-7969-1972)
- Theo Gülen (ORCID: https://orcid.org/0000-0002-1683-8882)
- Johannes Lübke (ORCID: https://orcid.org/0000-0003-0767-1504)
- Mariarita Sciumé (ORCID: https://orcid.org/0000-0001-7958-4966)
- Olivier Lortholary (ORCID: https://orcid.org/0000-0002-8325-8060)
- Gandhi Laurent Damaj (ORCID: https://orcid.org/0000-0002-4689-3882)
- Ilaria Tanasi (ORCID: https://orcid.org/0000-0001-8177-374X)
- Michael Doubek
- Olivier Hermine (ORCID: https://orcid.org/0000-0003-2574-3874)
- Jason R. Gotlib (ORCID: https://orcid.org/0000-0001-8253-6156)
- Madlen Jentzsch (ORCID: https://orcid.org/0000-0002-2270-0804)
- Delia Soare
- Nikolas C. C. von Bubnoff (ORCID: https://orcid.org/0000-0001-9593-8947)
- Massimiliano Bonifacio (ORCID: https://orcid.org/0000-0003-0716-1686)
- Ingunn Dybedal (ORCID: https://orcid.org/0000-0002-3229-3069)
- Stéphane Barète (ORCID: https://orcid.org/0000-0003-1593-9750)
- Luca Malcovati (ORCID: https://orcid.org/0000-0002-1460-1611)
- Wolfgang R. Sperr (ORCID: https://orcid.org/0000-0003-3288-8027)
- Roberta Parente (ORCID: https://orcid.org/0000-0002-4187-6477)
- Karin Hartmann (ORCID: https://orcid.org/0000-0002-4595-8226)
- Clement Gourguechon (ORCID: https://orcid.org/0000-0003-0740-2419)
- Hanneke Oude Elberink (ORCID: https://orcid.org/0000-0003-2844-2196)
- Polina Pyatilova (ORCID: https://orcid.org/0000-0001-5520-2900)
- Orianne Debeaupuis (ORCID: https://orcid.org/0000-0002-1393-3980)
- Laurent Frenzel (ORCID: https://orcid.org/0000-0002-6085-2163)
- Andreas Reiter (ORCID: https://orcid.org/0000-0002-6338-2136)
- Nicole Nojarov
- Daniel Baffoe
- Alex Stefan
- Judit Várkonyi (ORCID: https://orcid.org/0000-0002-0021-0003)
- Stephan de Bra
- Tobias Michael Franz (ORCID: https://orcid.org/0009-0007-1855-326X)
Institutions
- Semmelweis University (HU)
- Johannes Kepler University of Linz (AT)
- Oslo University Hospital (NO)
- Hôpital Necker-Enfants Malades (FR)
- University of Salerno (IT)
- University Medical Center Groningen (NL)
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- University of Padua (IT)
- University of Antwerp (BE)
- Inserm (FR)
- University of Freiburg (DE)
- University of Groningen (NL)
- University of Basel (CH)
- Medical University of Graz (AT)
- Université Paris Cité (FR)
- Masaryk University (CZ)
- Heidelberg University (DE)
- Clinical Emergency Hospital Bucharest (RO)
- University Medical Center Freiburg (DE)
- Erasmus MC (NL)
- University Hospital Heidelberg (DE)
- University Hospital of Basel (CH)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Sorbonne Université (FR)
- Hôpital Cochin (FR)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Antwerp University Hospital (BE)
- University Hospital Brno (CZ)
- University Hospital Schleswig-Holstein (DE)
- Hôpital Lyon Sud (FR)
- Kepler Universitätsklinikum (AT)
- Luzerner Kantonsspital (CH)
- Pitié-Salpêtrière Hospital (FR)
- ASST Melegnano e della Martesana (IT)
- University Hospital Leipzig (DE)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- University Clinical Centre (PL)
- Stanford Medicine (US)
- Azienda Ospedale - Università Padova (IT)
- Policlinico San Matteo Fondazione (IT)
- University Medical Centre Mannheim (DE)
- Kantonsspital Aarau (CH)
- Institut des Maladies Génétiques Imagine (FR)
- Bucharest Emergency University Hospital (RO)
- Stanford Cancer Institute (US)
- Technical University of Munich (DE)
- Istanbul University (TR)
- Gdańsk Medical University (PL)
- Medical University of Vienna (AT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
- Stanford University (US)
- KU Leuven (BE)
Publication Details
- Journal
- Blood
- Published
- 2026-11-05
- DOI
- https://doi.org/10.1182/blood.2026035465
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00