Tyrosine kinase inhibitors are associated with reduced AML transformation in systemic mastocytosis with myeloid neoplasm

In an international registry analysis of 201 patients with SM-AHN, KIT D816V-selective TKI exposure was associated with longer overall survival (37.9 vs 17.8 months; P <.001) and lower 36-month incidence of acute myeloid leukemia transformation (5.9% vs 27.1%; P <.001).

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Publication Details

Journal
Blood
Published
2026-11-05
DOI
https://doi.org/10.1182/blood.2026035465
Primary Topic
Mast cells and histamine
Type
article
Field-Weighted Citation Impact
0.00
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article

Tyrosine kinase inhibitors are associated with reduced AML transformation in systemic mastocytosis with myeloid neoplasm

Cristina Bulai Livideanu, Johannes Nikolaus Woltsche, Maël Heiblig, Peter Valent et al.
Blood
Mast cells and histamine
article

Tyrosine kinase inhibitors are associated with reduced AML transformation in systemic mastocytosis with myeloid neoplasm

Cristina Bulai Livideanu, Johannes Nikolaus Woltsche, Maël Heiblig, Peter Valent, Julien Rossignol, Akif Selim Yavuz, Paul L. A. van Daele, Deborah Christen, Jens Panse, Sophie Dimicoli, Andrzej Mital, Knut Brockow, Michael P. Makris, Mattias Mattsson, Chiara Elena, Irena Angelova‐Fischer, Christine M. Breynaert, Martina Sperr, Marc Heizmann, Juliana Schwaab, Friederike Wortmann, Marek Niedoszytko, Horia Bumbea, Valentina Bellani, Sotirios G. Papageorgiou, Michel Arock, Hanneke C. Kluin‐Nelemans, Vito Sabato, Anna Belloni Fortina, Saskia K. Klein, Massimo Triggiani, Axel Rüfer, Aleksandra Górska, Olivier Tournilhac, Frank Siebenhaar, Simge Erdem, Khalid Shoumariyeh, Theo Gülen, Johannes Lübke, Mariarita Sciumé, Olivier Lortholary, Gandhi Laurent Damaj, Ilaria Tanasi, Michael Doubek, Olivier Hermine, Jason R. Gotlib, Madlen Jentzsch, Delia Soare, Nikolas C. C. von Bubnoff, Massimiliano Bonifacio, Ingunn Dybedal, Stéphane Barète, Luca Malcovati, Wolfgang R. Sperr, Roberta Parente, Karin Hartmann, Clement Gourguechon, Hanneke Oude Elberink, Polina Pyatilova, Orianne Debeaupuis, Laurent Frenzel, Andreas Reiter, Nicole Nojarov, Daniel Baffoe, Alex Stefan, Judit Várkonyi, Stephan de Bra, Tobias Michael Franz
article en

Abstract

In an international registry analysis of 201 patients with SM-AHN, KIT D816V-selective TKI exposure was associated with longer overall survival (37.9 vs 17.8 months; P <.001) and lower 36-month incidence of acute myeloid leukemia transformation (5.9% vs 27.1%; P <.001).

Blood
Semmelweis University (HU), Johannes Kepler University of Linz (AT), Oslo University Hospital (NO), Hôpital Necker-Enfants Malades (FR), University of Salerno (IT), University Medical Center Groningen (NL), Karolinska University Hospital (SE), Uppsala University Hospital (SE), University of Padua (IT), University of Antwerp (BE), Inserm (FR), University of Freiburg (DE), University of Groningen (NL), University of Basel (CH), Medical University of Graz (AT), Université Paris Cité (FR), Masaryk University (CZ), Heidelberg University (DE), Clinical Emergency Hospital Bucharest (RO), University Medical Center Freiburg (DE), Erasmus MC (NL), University Hospital Heidelberg (DE), University Hospital of Basel (CH), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Centre Hospitalier Universitaire de Bordeaux (FR), Centre Hospitalier Universitaire de Toulouse (FR), Sorbonne Université (FR), Hôpital Cochin (FR), Azienda Ospedaliera Universitaria Integrata Verona (IT), Centre Hospitalier Universitaire Amiens-Picardie (FR), Assistance Publique – Hôpitaux de Paris (FR), Antwerp University Hospital (BE), University Hospital Brno (CZ), University Hospital Schleswig-Holstein (DE), Hôpital Lyon Sud (FR), Kepler Universitätsklinikum (AT), Luzerner Kantonsspital (CH), Pitié-Salpêtrière Hospital (FR), ASST Melegnano e della Martesana (IT), University Hospital Leipzig (DE), Centre Hospitalier Universitaire de Clermont-Ferrand (FR), University Clinical Centre (PL), Stanford Medicine (US), Azienda Ospedale - Università Padova (IT), Policlinico San Matteo Fondazione (IT), University Medical Centre Mannheim (DE), Kantonsspital Aarau (CH), Institut des Maladies Génétiques Imagine (FR), Bucharest Emergency University Hospital (RO), Stanford Cancer Institute (US), Technical University of Munich (DE), Istanbul University (TR), Gdańsk Medical University (PL), Medical University of Vienna (AT), Charité - Universitätsmedizin Berlin (DE), University of Lübeck (DE), Stanford University (US), KU Leuven (BE)
Openalex Percentile: Top 21%
Mast cells and histamine
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