COSMOBIOLOGY OF MIRNY. NOTE NO. 17: THE ELDERLINE. QUANTUM COOPERATIVITY, ENVIRONMENTAL MEMORY, AND THE DOMAIN LADDER

The first note on thesis No. 5 (biology) from Mirny's notes No. 15 closes the two-day cycle: from the massive unloading of Hill coefficients from SABIO-RK (236 entries) after three zero results, which turned out to be a confirmation of symmetry, to a specific memory mechanism of the environment. The test protein became an `Elder" --- UDP-\textit{N}-acetylglucosamine 2-epimerase (EC~5.1.3.14), a family that has survived to all three modern domains of life. The main results: (1)~the protein cooperativity coefficient $n$ is quantized. the oligomeric state of the carrier --- ladder $1{,}94 \to 2{,}0 \to 2{,}3 \to 2{,}7 \to 0{,}45/4{,}1$ It reads like a ladder of numbers binding sites; (2)~two cubes coexist in one protein - substrate ($n = 0{,}45$, anticooperative input) and grocery ($n = 4{,}1$, feedback switch); (3)~the memory of the medium has a measured molecular carrier: the loop of reassembly of the oligomer lives hours versus microseconds of the catalytic cycle. All statuses are named by the fact that they exist; scientific predecessors are indicated with gratitude.