Genome-wide scan for transmission ratio distortion in trios from the Norwegian MoBa cohort rules out moderate distortion at common variants
Abstract Transmission ratio distortion has been demonstrated in model organisms but is understudied in humans. We conduct single- and multi-locus transmission disequilibrium tests to detect transmission ratio distortion in up to 43,829 parent–offspring trios from the Norwegian Mother, Father and Child Cohort Study. We find little evidence for moderate to high levels of transmission ratio distortion at common variants. However, our multi-locus analyses implicate genes involved in meiosis, fertility, and prenatal development.
Authors
- Liang‐Dar Hwang (ORCID: https://orcid.org/0000-0002-5535-2199)
- George Davey Smith (ORCID: https://orcid.org/0000-0002-1407-8314)
- Gibran Hemani (ORCID: https://orcid.org/0000-0003-0920-1055)
- Astanand Jugessur (ORCID: https://orcid.org/0000-0003-1365-8322)
- Laurie J. Hannigan (ORCID: https://orcid.org/0000-0003-3123-5411)
- Shannon D’Urso (ORCID: https://orcid.org/0000-0002-1567-6762)
- Elizabeth C. Corfield (ORCID: https://orcid.org/0000-0002-0119-157X)
- Kasper Munch (ORCID: https://orcid.org/0000-0003-2880-6252)
- David M. Evans (ORCID: https://orcid.org/0000-0003-0663-4621)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-6427-2625)
- Alexandra Havdahl (ORCID: https://orcid.org/0000-0002-9268-0423)
- Gunn-Helen Moen
Institutions
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- The University of Queensland (AU)
- University of Oslo (NO)
- Aarhus University (DK)
- Norwegian University of Science and Technology (NO)
- University of Bristol (GB)
- Mater Research (AU)
- Lovisenberg Diakonale Sykehus (NO)
- MRC Integrative Epidemiology Unit (GB)
- Institute for Molecular Bioscience (AU)
- University of Bergen (NO)
Publication Details
- Journal
- Genome biology
- Published
- 2026-11-05
- DOI
- https://doi.org/10.1186/s13059-026-04333-2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00