The Role and Mechanism of Ultrasound-Responsive Transcriptional Repressors in Bone Remodeling

Currently, ultrasound has achieved certain clinical efficacy in promoting bone remodeling, but its signal transduction mechanisms have not yet been fully elucidated, leading to significant individual differences in clinical outcomes. Transcription factors, as core regulatory elements that enable cells to perceive environmental changes, play critical roles in the sensing, transduction, and response to physical stimuli. In the field of ultrasound therapy, several positive transcription factors have been reported to be activated by ultrasound stimulation, thereby promoting cell proliferation, differentiation, and tissue repair. However, inhibitory transcription factors that function as a "brake" mechanism remain largely unexplored. If the braking effect of these inhibitory transcription factors can be relieved, it may offer a novel strategy to enhance the therapeutic efficacy of ultrasound. Therefore, the objective of this project is to identify key transcriptional repressors and elucidate their "molecular brake" mechanisms, which holds important scientific significance for "releasing the brake" and accelerating ultrasound-promoted bone remodeling.