Disease associated gut microbiota and plasma metabolite alterations in schizophrenia patients with comorbid metabolic syndrome

Schizophrenia and metabolic syndrome are both chronic diseases with complex etiologies, yet the mechanisms underlying their comorbidity remain elusive. The development of both schizophrenia and metabolic syndrome is intricately linked to the gut microbiota, while circulating metabolites may serve as promising pathological indicators. Here, we conducted 16S rRNA gene sequencing on gut microbiota, plasma gas chromatography-mass spectrometry combined with ultra-performance liquid chromatography-mass spectrometry untargeted metabolomics detection on 79 schizophrenia patients with comorbid metabolic syndrome, 71 schizophrenia patients without comorbid metabolic syndrome, and 60 controls. The aim was to explore the gut microbiota and circulating metabolic characteristics related to schizophrenia with comorbid metabolic syndrome.