Neutrophil-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio, and Platelet-to-Lymphocyte Ratio in Erythema Nodosum Leprosum

Leprosy is a chronic, slowly progressive infectious disease caused by Mycobacterium leprae. The disease can cause extensive and permanent deformities of the skin and peripheral nerves, potentially resulting in severe and irreversible disabilities. A major challenge in the management of patients with leprosy is the development of leprosy reactions, which may occur at any stage of the disease. Identifying laboratory markers that can predict the occurrence and course of leprosy reactions remains a priority in leprosy research aimed at preventing irreversible nerve damage. This study aimed to determine the diagnostic value of inflammatory markers that may accurately indicate the severity of leprosy reactions. This study employed an analytical cross-sectional design. Samples were collected from patients who met the inclusion criteria at Haulussy Regional General Hospital and other affiliated hospitals and primary health centers in Ambon City, Maluku. A total of 20 samples were included. Blood samples were collected from the patients for laboratory analysis. The neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio were increased in patients with leprosy reactions; however, the differences were not statistically significant.