Successful treatment of pritelivir in an immunocompromised pediatric patient with refractory/resistant HSV-1 infection: a first report with therapeutic drug monitoring
Abstract Management of refractory and resistant (R/R) Herpes Simplex Virus (HSV-1) infections in hematopoietic stem cell transplant (HSCT) recipients remains challenging. Literature on pritelivir’s efficacy in pediatric patients is scarce. We successfully treated a 7-year-old HSCT recipient with pritelivir for an (R/R) HSV-1 infection and performed therapeutic drug monitoring.
Authors
- Christine Zandotti
- Minh Pierre Lê
- Sandrine Visentin (ORCID: https://orcid.org/0000-0003-4712-4214)
- Paul Saultier (ORCID: https://orcid.org/0000-0002-6327-0898)
- Vincent Barlogis (ORCID: https://orcid.org/0000-0001-9645-3968)
- Hérvè Chambost (ORCID: https://orcid.org/0000-0002-5319-1969)
- Claire Goudet
- Gilles Peytavin (ORCID: https://orcid.org/0000-0002-4359-537X)
- Léa Lucıanı (ORCID: https://orcid.org/0000-0002-0738-5957)
- Pierre Frange (ORCID: https://orcid.org/0000-0002-4920-8369)
- Charlotte Bérard (ORCID: https://orcid.org/0000-0002-6030-8352)
- Ambre Dethier (ORCID: https://orcid.org/0009-0001-3534-9021)
- Léna Pessarossi
- Morgane Sighieri (ORCID: https://orcid.org/0009-0005-1239-1154)
- Caroline SOLAS
- Mégane Allegro
- Hugo Bes Berlandier
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Université Sorbonne Paris Nord (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Hôpital de la Timone (FR)
- Institut de Recherche pour le Développement (FR)
- Infection, Anti-microbiens, Modélisation, Evolution (FR)
- Unité des Virus Emergents (FR)
Publication Details
- Journal
- Research Square
- Published
- 2026-11-04
- DOI
- https://doi.org/10.21203/rs.3.rs-11402412/v1
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- preprint