Complete NMR Structural Elucidation, Conformation, and Cytotoxic Evaluation of Polystachyne I, a New neo ‐Clerodane Diterpenoid From Salvia polystachya
ABSTRACT Chemical investigation of the aerial parts of Salvia polystachya Ortega afforded a new neo ‐clerodane‐type diterpenoid named polystachyne I ( 1 ) and the previously known diterpenoid microphyllandiolide ( 2 ). Their structures were elucidated by 1D and 2D NMR experiments. The absolute configuration of 1 was established by single‐crystal X‐ray diffraction. Compound 1 was tested for cytotoxicity against three human cancer cell lines, showing moderate activity.
Authors
- Miguel Ángel Fuentes-Figueroa (ORCID: https://orcid.org/0000-0001-7573-0639)
- Rogelio Pereda‐Miranda (ORCID: https://orcid.org/0000-0002-0542-0085)
- Rubén Alfredo Toscano (ORCID: https://orcid.org/0000-0002-4380-9251)
- Elihú Bautista (ORCID: https://orcid.org/0000-0002-7050-9182)
- Luis A. Salazar‐Olivo (ORCID: https://orcid.org/0000-0001-6906-4561)
- Mabel Fragoso‐Serrano (ORCID: https://orcid.org/0000-0002-7693-8391)
- Itzi Fragoso-Martínez (ORCID: https://orcid.org/0000-0003-3661-1076)
- Omar Cortezano-Arellano (ORCID: https://orcid.org/0000-0003-3442-9246)
- Jennifer Alexis Rojas-Morales (ORCID: https://orcid.org/0000-0002-0412-5156)
- Susana Madrigal-Ortiz (ORCID: https://orcid.org/0000-0002-8519-6131)
- Ana K. Tinajero‐Acevedo
Institutions
- Universidad Veracruzana (MX)
- Institute for Scientific and Technological Research (MX)
- Instituto de Ecología (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Magnetic Resonance in Chemistry
- Published
- 2026-11-04
- DOI
- https://doi.org/10.1002/mrc.70152
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00