Beyond P ‐values and means: Statistical appreciation in the life sciences

Statistical literacy is frequently treated in undergraduate and graduate life science training as a technical competency peripheral to experimental practice rather than as a central component of scientific reasoning. This separation is especially problematic in life sciences and related disciplines, where biological variability is intrinsic to living systems and often gives rise to heterogeneous, skewed, multiplicative and non-normal data. Consequently, the interpretation of biological measurements depends not only on the data themselves but also on how variability, distributions, measurement scale, uncertainty and inference are understood. This perspective argues that stronger statistical appreciation is urgently needed in the life sciences, particularly during early scientific training. Emphasis is placed on the biological origins of variability, the interpretation of distributions, the importance of multiplicative thinking and lognormality, the appropriate use of means, medians, geometric means and logarithmic transformations, and the distinction between variability, uncertainty and effect size. The article further discusses replication, outliers, the limitations of significance testing and why statistical thinking should be embedded within bioscience education as an integral part of scientific reasoning rather than taught as an isolated analytical skill.

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Publication Details

Journal
FEBS Journal
Published
2026-11-03
DOI
https://doi.org/10.1111/febs.70779
Primary Topic
Statistics Education and Methodologies
Type
article
Field-Weighted Citation Impact
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article

Beyond P ‐values and means: Statistical appreciation in the life sciences

Bharath Srinivasan
FEBS Journal
Statistics Education and Methodologies
article

Beyond P ‐values and means: Statistical appreciation in the life sciences

Bharath Srinivasan
article en

Abstract

Statistical literacy is frequently treated in undergraduate and graduate life science training as a technical competency peripheral to experimental practice rather than as a central component of scientific reasoning. This separation is especially problematic in life sciences and related disciplines, where biological variability is intrinsic to living systems and often gives rise to heterogeneous, skewed, multiplicative and non-normal data. Consequently, the interpretation of biological measurements depends not only on the data themselves but also on how variability, distributions, measurement scale, uncertainty and inference are understood. This perspective argues that stronger statistical appreciation is urgently needed in the life sciences, particularly during early scientific training. Emphasis is placed on the biological origins of variability, the interpretation of distributions, the importance of multiplicative thinking and lognormality, the appropriate use of means, medians, geometric means and logarithmic transformations, and the distinction between variability, uncertainty and effect size. The article further discusses replication, outliers, the limitations of significance testing and why statistical thinking should be embedded within bioscience education as an integral part of scientific reasoning rather than taught as an isolated analytical skill.

FEBS Journal
Cancer Research UK (GB), Cancer Research UK Cambridge Center (GB), Robert Gordon University (GB), Stony Brook University (US)
Openalex Percentile: Top 15%
Statistics Education and Methodologies
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