Higher-order interactions renormalize the thermodynamic signature of neural population codes

Maximum-entropy models of neural recordings can be treated as Boltzmann distributions at a fictitious temperature $T$, with the fitted model at $T=1$. Their specific-heat peak grows with population size and approaches that temperature, which has been read as a sign of criticality. The case rests on pairwise models, yet retinal codes require higher-order interactions. The thermodynamics of a model with such interactions fitted cell by cell has not been computed. Here I compute it exactly for pairwise and third-order models of the same populations of up to $20$ retinal ganglion cells, in salamander and marmoset. The triplet terms, required by the held-out likelihood, shift the peak by more than the finite-sample bias, with opposite sign in the two retinas. The peak is lower and grows more slowly in salamander, higher and grows faster in marmoset, and lies closer to $T=1$ in both. An exact decomposition traces most of the shift to the energy variance across population spike counts. A constraint on the spike-count distribution alone reproduces all of it in salamander and over half in marmoset. A second recording of each species, re-binning, and a common-input surrogate show that the sign is set by the spike-count structure of a recording at its temporal resolution, not by species. The thermodynamic signature of a neural code is therefore set not by the data alone but by the interaction order of the model used to read it.

Authors

Publication Details

Journal
arXiv (Cornell University)
Published
2026-11-03
DOI
https://doi.org/10.48550/arxiv.2611.05336
Primary Topic
Neural dynamics and brain function
Type
preprint
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preprint

Higher-order interactions renormalize the thermodynamic signature of neural population codes

Narendra N. Hegade
arXiv (Cornell University)
Neural dynamics and brain function
preprint

Higher-order interactions renormalize the thermodynamic signature of neural population codes

Narendra N. Hegade
preprint en

Abstract

Maximum-entropy models of neural recordings can be treated as Boltzmann distributions at a fictitious temperature $T$, with the fitted model at $T=1$. Their specific-heat peak grows with population size and approaches that temperature, which has been read as a sign of criticality. The case rests on pairwise models, yet retinal codes require higher-order interactions. The thermodynamics of a model with such interactions fitted cell by cell has not been computed. Here I compute it exactly for pairwise and third-order models of the same populations of up to $20$ retinal ganglion cells, in salamander and marmoset. The triplet terms, required by the held-out likelihood, shift the peak by more than the finite-sample bias, with opposite sign in the two retinas. The peak is lower and grows more slowly in salamander, higher and grows faster in marmoset, and lies closer to $T=1$ in both. An exact decomposition traces most of the shift to the energy variance across population spike counts. A constraint on the spike-count distribution alone reproduces all of it in salamander and over half in marmoset. A second recording of each species, re-binning, and a common-input surrogate show that the sign is set by the spike-count structure of a recording at its temporal resolution, not by species. The thermodynamic signature of a neural code is therefore set not by the data alone but by the interaction order of the model used to read it.

arXiv (Cornell University)
Neural dynamics and brain function
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