What is the relationship between abdominal aortic aneurysm (AAA) and ASXL1 mutations regarding genetic predisposition or risk factors?

ASXL1 mutations in clonal hematopoiesis significantly increase the risk of developing an abdominal aortic aneurysm, primarily through activation of inflammatory pathways. Observational studies support strong associations but not causality, highlighting the need for further research.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-04
DOI
https://doi.org/10.5281/zenodo.23955147
Primary Topic
Aortic aneurysm repair treatments
Type
article
Field-Weighted Citation Impact
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article

What is the relationship between abdominal aortic aneurysm (AAA) and ASXL1 mutations regarding genetic predisposition or risk factors?

Tripdatabase
Zenodo (CERN European Organization for Nuclear Research)
Aortic aneurysm repair treatments
article

What is the relationship between abdominal aortic aneurysm (AAA) and ASXL1 mutations regarding genetic predisposition or risk factors?

Tripdatabase
article en

Abstract

ASXL1 mutations in clonal hematopoiesis significantly increase the risk of developing an abdominal aortic aneurysm, primarily through activation of inflammatory pathways. Observational studies support strong associations but not causality, highlighting the need for further research.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 13%
Aortic aneurysm repair treatments
DOIOpen Access PDFOpenAlex
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What is the relationship between abdominal aortic aneurysm (AAA) and ASXL1 mutations regarding genetic predisposition or risk factors? — Tripdatabase · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS