Learning to Falsify: Hierarchical Multiple Instance Learning for High Resolution AI-Generated Image Detection

Recent advances in generative models have made synthetic images increasingly photorealistic, posing growing challenges to reliable and generalizable detection of AI-generated images. Existing methods typically rely on holistic image-level classification, which may overlook local artifacts, especially in high-resolution images. To address this limitation, we formulate this task as a falsification-driven multiple instance learning problem, where a single fake patch can falsify the whole image, while a real image requires all patches to be authentic. Based on this formulation, we propose \textit{Learning to Falsify (LTF)}, a hierarchical multiple instance learning framework that models an image as multiple bags of instances across different spatial levels and aggregates their predictions under the falsification-inspired principle. We further introduce Cross-Shuffle during training to encourage the model to learn local artifact evidence rather than image-level shortcuts. Furthermore, we propose the \textit{Falsification-driven Test-time Aggregation Strategy (FATAS)}, a plug-and-play module that extends the same falsification-inspired principle to existing detectors by aggregating patch-level predictions. Extensive experiments demonstrate that LTF achieves strong generalization and robustness across multiple benchmarks, while FATAS substantially improves representative detectors in high-resolution scenarios without retraining. Code is available at https://github.com/HuiGuanLab/LTF.git