CACA guidelines for holistic integrative management of cancer-related respiratory system injury

Abstract The respiratory system is a frequent site of primary and metastatic malignancies. Tumor-related respiratory injury encompasses a wide spectrum of disorders arising from direct invasion, obstruction, metastatic spread, and complications of anticancer therapies. This guideline provides a comprehensive framework for the holistic, integrative management of these conditions, based on a synthesis of current evidence and clinical expertise. It begins with an overview of respiratory system structure and function, followed by a detailed analysis of the mechanisms by which tumors cause respiratory damage. Subsequent chapters address the diagnosis and management of specific clinical entities, including tumor-associated pulmonary infections, cancer-associated thromboembolism, airway obstruction, and respiratory failure. A major focus is placed on the spectrum of treatment-related lung injuries, including those induced by surgery, radiation therapy, chemotherapy, molecular targeted agents, anti-angiogenic therapy, and immune checkpoint inhibitors. The guideline concludes with considerations for managing malignancies in patients with pre-existing chronic lung diseases. The overarching goal is to standardize diagnosis and treatment strategies, thereby improving outcomes for patients with tumor-related respiratory system injuries through a multidisciplinary, integrated approach.

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Publication Details

Journal
Holistic Integrative Oncology
Published
2026-11-04
DOI
https://doi.org/10.1007/s44178-026-00300-w
Primary Topic
Lung Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

CACA guidelines for holistic integrative management of cancer-related respiratory system injury

Pinhua Pan, Mengshu Cao, Songmin Ying, 张国俊 et al.
Holistic Integrative Oncology
Lung Cancer Diagnosis and Treatment
article

CACA guidelines for holistic integrative management of cancer-related respiratory system injury

Pinhua Pan, Mengshu Cao, Songmin Ying, 张国俊, Panwen Tian, Dan Liu, Yuanyuan Li, Chunrong Ju, Ruirui Cheng, Xiaoxing Gao, Min Li, Yanming Li, Qiang Guo, Jing Zhang, Mengzhao Wang, Yahong Chen, Meng Yang, Kewu Huang, Bin Cao, Conghua Xie, Manxiang Li, Zhi Xu, Yongchang Zhang, Minjiang Chen
article en

Abstract

Abstract The respiratory system is a frequent site of primary and metastatic malignancies. Tumor-related respiratory injury encompasses a wide spectrum of disorders arising from direct invasion, obstruction, metastatic spread, and complications of anticancer therapies. This guideline provides a comprehensive framework for the holistic, integrative management of these conditions, based on a synthesis of current evidence and clinical expertise. It begins with an overview of respiratory system structure and function, followed by a detailed analysis of the mechanisms by which tumors cause respiratory damage. Subsequent chapters address the diagnosis and management of specific clinical entities, including tumor-associated pulmonary infections, cancer-associated thromboembolism, airway obstruction, and respiratory failure. A major focus is placed on the spectrum of treatment-related lung injuries, including those induced by surgery, radiation therapy, chemotherapy, molecular targeted agents, anti-angiogenic therapy, and immune checkpoint inhibitors. The guideline concludes with considerations for managing malignancies in patients with pre-existing chronic lung diseases. The overarching goal is to standardize diagnosis and treatment strategies, thereby improving outcomes for patients with tumor-related respiratory system injuries through a multidisciplinary, integrated approach.

Holistic Integrative OncologyVol. 5(1)
Shanghai Medical College of Fudan University (CN), Central South University (CN), Army Medical University (CN), Capital Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Sichuan University (CN), Fudan University (CN), Beijing Chao-Yang Hospital, Capital Medical University (CN), China-Japan Friendship Hospital (CN), Peking Union Medical College Hospital (CN), West China Hospital of Sichuan University (CN), First Affiliated Hospital of Guangzhou Medical University (CN), Nanjing Drum Tower Hospital (CN), Hunan Cancer Hospital (CN), Beijing Hospital (CN), Zhongnan Hospital of Wuhan University (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Zhongshan Hospital (CN), Peking University Third Hospital (CN), State Key Laboratory of Respiratory Disease (CN), First Affiliated Hospital of Zhengzhou University (CN), Second Affiliated Hospital of Zhejiang University (CN), Xiangya Hospital Central South University (CN), Center for Life Sciences (CN), The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital) (CN), Guangzhou Institute of Respiratory Health (CN), Zhejiang University (CN), Xi'an Jiaotong University (CN), Tsinghua University (CN)
Openalex Percentile: Top 13%
Lung Cancer Diagnosis and Treatment
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