The Relationship Between Toxoplasma Gondii Infection And Immunological, Hormonal And Antioxidant Parameters In Women Who Have Experienced Abortion

Toxoplasma gondii is an intracellular opportunistic protozoan that is among the most common acute or latent abortifacient zoonoses. The study aimed to measured the level of some immunological, hormonal and oxidative stress parameters in women suffered from abortion. Eighty blood samples were collected from women experiencing miscarriages and twenty samples from healthy women. The diagnosis were carried out by toxoplasma rapid test. The measurement of Interleukins, hormones and antioxidants were carried out by ELISA and Cobas device. The results of T. gondii diagnosis in eighty women after abortion showed that 40% of them were positive for IgG while 23.7% were positive for IgM in rapid diagnosis test . The patients group showed significant high mean level of IL-17A, IL-27, Anti-Mullerian hormone and Prostaglandin (299.5± 51.5, 234.0± 25.8, 8844.5± 490, 1450.0± 75.60pg/ml) compared with healthy group (201.8± 65.9, 160.5± 20.1, 300.3± 33.0, 9.6± 1.2 pg/ml) with (p˂0.001).The patients group showed significant low mean level of Gpxs and GSH (119.9± 10.1, 3.75± 0.11pg/ml) compared with healthy group (300.3± 33.0, 9.6± 1.2pg/ml) with (p˂0.001). IgG antibodies were more common than IgM antibodies in women with a history of abortion in this investigation. The increase in blood IL-17A and IL-27 levels suggests an altered immune response linked to these women's inflammatory and immunoregulatory processes. The greater levels of anti-Müllerian hormone (AMH) and prostaglandin and the lower levels of glutathione peroxidase (GPx) and glutathione (GSH) reflect hormonal and inflammatory alterations and a compromised antioxidant defence. These findings suggest that women with abortion histories should be tested for immunological, hormonal, and oxidative stress indicators.