Challenging Cytologic Diagnosis of Intrahepatic Cholangiocarcinoma Arising in Ductal Plate Malformation
This case describes a rare intrahepatic cholangiocarcinoma arising in a background of ductal plate malformation/Von Meyenburg complex. Predominant sampling of benign ductal proliferations obscured a focal malignant component, highlighting the importance of recognizing subtle cytomorphologic atypia, correlating pathologic findings with imaging, and utilizing ancillary studies to establish the diagnosis.
Authors
- Lucy Jager (ORCID: https://orcid.org/0000-0003-3000-3686)
- Xiaoqi Lin (ORCID: https://orcid.org/0000-0002-0760-3950)
- Lawrence J. Jennings (ORCID: https://orcid.org/0000-0001-8669-7774)
- Andrew C. Gordon (ORCID: https://orcid.org/0000-0002-0092-249X)
- Jeffrey Zijie Lin (ORCID: https://orcid.org/0009-0006-7497-5902)
Institutions
- Northwestern University (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Cytopathology
- Published
- 2026-11-02
- DOI
- https://doi.org/10.1111/cyt.70144
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00