DESIGN, SYNTHESIS AND CHARACTERIZATION OF NOVEL OXAZOLE DERIVATIVES FOR EVALUATION OF ANTIFUNGAL ACTIVITY

Background: A number of heterocyclic derivatives containing nitrogen have been used as versatile scaffolds in drug development. Oxazole is one of the heterocyclic compounds with remarkable pharmacological activities. Oxazole derivatives were found to process the biological activities like Anti-convulsant, Anti-alzimer, Anti-hypertensive, Anti-cancer, Anti-HIV, Anti-inflammatory, Anthelmintic activities. Due to its potent and significant biological activities it has great pharmaceutical importance; hence, synthesis of this compound is of considerable interest. Objective: To synthesize the 4-substituted 2-amino 1,3 Oxazole derivatives and recrystallized, characterized by m.p, Rf, FTIR, 1h NMR, mass data. Methods: The molecular property prediction of all the synthesized compounds by using Lipinski's rule of 5, PASS, OSIRIS molecular property explorer, Molsoft, Docking softwares. The all compounds were synthesized by conventional method. The synthesized compounds were evaluated anti fungal activity by using Yeast as a model system for anticancer study. Results: All the compounds shows the good percentage yields. All the compounds were obeys the lipinski's rule, non-toxic, drug likeness and more active and shows the good binding affinities when compared with the standard drug (Ciprofloxacin). The all compounds were more and equal potent when compared to standard drug, Ciprofloxacin. Conclusion: The compounds 4a, 4c and 4e shows the good results in the molecular property prediction and biological evaluation.