Two Patients. Different Cancers. One New Scientific Discovery Infrastructure.

This paper proposes a human-led scientific discovery infrastructure for federated oncology research. It examines how independently controlled research environments can contribute authorized computation and evidence without surrendering control of underlying records, methods or intellectual property. The framework connects M5 Scientific Calculators, bounded AI-agent roles, provenance, qualified human scientific review and accountable research governance. Within the wider M5Labs research program, iWBE (Intelligent Women Business Enterprise) and iSWE (Intelligent Society of Women Engineers) are initiatives defined within the M5Labs research framework. They propose an AI- and blockchain-powered approach to accelerating the participation of women-owned and women-led enterprises, women engineers and women scientists in business, scientific research and economic opportunity. Through human-directed AI agents, scientific calculators and accountable research infrastructure, the initiatives aim to help participants develop capabilities, build enterprises and retain control of their work and applicable intellectual-property rights. iSWE is an independently defined initiative and is not affiliated with or endorsed by the Society of Women Engineers (SWE). The accompanying M5Labs Technical Verification Appendix provides supporting technical context. The paper presents a research framework; its scientific scope, assumptions, evidence and limitations are set out in the manuscript.