Occult Hemotoxic Envenomation presenting as Fulminant Septic Shock with Disseminated Intravascular Coagulation in a Young Male: A Diagnostic Challenge.

We report a case of a previously healthy 17-year male who presented with a sudden onset of fever, severe myalgia, altered sensorium, and rapidly progressive shock. Initial evaluation revealed severe metabolic acidosis, thrombocytopenia, acute kidney injury, and markedly elevated inflammatory markers, raising suspicion for fulminant septic shock with multiorgan dysfunction. Broad-spectrum antimicrobial therapy and intensive supportive care was initiated. Microbiological cultures from blood, urine, and cerebrospinal fluid were sterile. The clinical course was further complicated by early development of purpura fulminans and laboratory evidence of disseminated intravascular coagulopathy. A diagnostic turning point occurred following the incidental identification of two punctate scabbed lesions over the lateral aspect of the foot, suggestive of a possible bite mark. In the context of sterile cultures, abrupt disease progression, and consumptive coagulopathy, occult snake bite with venom-induced consumptive coagulopathy was strongly considered. The patient demonstrated gradual recovery with vasopressor and other organ support in ICU. This case highlights a rare but important diagnostic dilemma in which occult hemotoxic envenomation closely mimicked fulminant septic shock. In endemic regions, snakebite envenomation should be considered in patients presenting with hyperacute shock, coagulopathy, and multiorgan dysfunction, particularly when microbiological evidence of infection is lacking.

Authors

Publication Details

Journal
Journal of Nepalese Society of Critical Care Medicine
Published
2026-11-03
DOI
https://doi.org/10.67570/jnsccm.v5i1.156
Primary Topic
Venomous Animal Envenomation and Studies
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Occult Hemotoxic Envenomation presenting as Fulminant Septic Shock with Disseminated Intravascular Coagulation in a Young Male: A Diagnostic Challenge.

Sarbagya Manandhar, Laliteshwar Shah, Shristee Chudal, Sishir Siwakoti
Journal of Nepalese Society of Critical Care Medicine
Venomous Animal Envenomation and Studies
article

Occult Hemotoxic Envenomation presenting as Fulminant Septic Shock with Disseminated Intravascular Coagulation in a Young Male: A Diagnostic Challenge.

Sarbagya Manandhar, Laliteshwar Shah, Shristee Chudal, Sishir Siwakoti
article en

Abstract

We report a case of a previously healthy 17-year male who presented with a sudden onset of fever, severe myalgia, altered sensorium, and rapidly progressive shock. Initial evaluation revealed severe metabolic acidosis, thrombocytopenia, acute kidney injury, and markedly elevated inflammatory markers, raising suspicion for fulminant septic shock with multiorgan dysfunction. Broad-spectrum antimicrobial therapy and intensive supportive care was initiated. Microbiological cultures from blood, urine, and cerebrospinal fluid were sterile. The clinical course was further complicated by early development of purpura fulminans and laboratory evidence of disseminated intravascular coagulopathy. A diagnostic turning point occurred following the incidental identification of two punctate scabbed lesions over the lateral aspect of the foot, suggestive of a possible bite mark. In the context of sterile cultures, abrupt disease progression, and consumptive coagulopathy, occult snake bite with venom-induced consumptive coagulopathy was strongly considered. The patient demonstrated gradual recovery with vasopressor and other organ support in ICU. This case highlights a rare but important diagnostic dilemma in which occult hemotoxic envenomation closely mimicked fulminant septic shock. In endemic regions, snakebite envenomation should be considered in patients presenting with hyperacute shock, coagulopathy, and multiorgan dysfunction, particularly when microbiological evidence of infection is lacking.

Journal of Nepalese Society of Critical Care Medicine
Openalex Percentile: Top 17%
Venomous Animal Envenomation and Studies
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Laika access coming soon