Factors influencing older adults’ intention to enroll in an Alzheimer's secondary prevention trial and to ask a study partner to enroll with them: results from a national survey

Abstract INTRODUCTION One barrier to successful completion of Alzheimer's secondary prevention trials is recruitment of inclusive samples. Methods A national survey of US adults ≥ 65 assessed salient beliefs underlying intention to enroll in a hypothetical secondary prevention trial of an investigational drug and, among those somewhat or very likely to enroll, intention to ask a study partner to participate with them. RESULTS Only 24.4% of respondents indicated that they were likely to enroll in the hypothetical trial. Within the subset of respondents likely to enroll, 61.3% indicated that they were likely to ask a study partner to participate with them. While there were no statistically significant differences in intention to enroll or to ask a partner between Black and White respondents, there were significant differences in the beliefs underlying those intentions. DISCUSSION Understanding beliefs’ underlying intention can inform the development of evidence‐based outreach messages and recruitment approaches to enhance representation.